Slco1b1 variation and disease therapy

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August undefined, 2024

WebApr 4, 2024 · Important genes involved in the variation in clinical events after statin therapy include the APOE, CETP, KIF6, ABCB1 and SLCO1B1 genes. However, those results are … WebFeb 12, 2024 · SLCO1B1 encodes a transporter (SLCO1B1; alternative names include OATP1B1 or OATP-C) that facilitates the hepatic uptake of all statins. ABCG2 encodes an efflux transporter (BCRP) that modulates the absorption and disposition of rosuvastatin. CYP2C9 encodes a phase I drug metabolizing enzyme responsible for the oxidation of …

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WebCholesterol 7α-hydroxylase (CYP7A1) is the rate-limiting enzyme of bile acid production in human beings, and organic anion-transporting polypeptide 1B1 (OATP1B1) may influence bile acid hepatic uptak WebInter-individual variation in clearance of methotrexate results in heterogeneous systemic exposure, clinical efficacy, and toxicity. In a genome-wide association study of children … flights from prg to bud

SLCO1B1 521T→C functional genetic polymorphism and lipid

WebAn SLCO1B1 variant with a C allele at nucleotide position rs4149056 has been associated with altered pharmacokinetics of the cholesterol-lowering drug simvastatin, as well as … WebOne of the potential contributing factors for the contrary result was thought to be related to the variation in disease types. For MMF-related adverse reactions, SLCO1B1 521T>C, UGT2B7 802C>T, and IMPDH1 −106G>A gene polymorphisms were associated with infections and adverse reactions of the hematologic system. WebSLCO1B1may be involved in the metabolism of triglycerides and HDL. We have provided a tool for identifying potentially high-risk groups that could be helpful for early diagnosis and prevention, individualized drug therapy and even gene therapy. KEYWORDS: SLCO1B1 genotype gene polymorphism genotyping blood lipid statins cardiovascular disease flights from prg to klu

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Full article: Association between SLCO1B1 polymorphism distribution …

WebSep 17, 2024 · Through assessment of prespecified secondary end points, Peyser et al 12 confirm that SAMS is a significant barrier to reducing cardiovascular risk. Performing … flights from prg to manWebJun 27, 2013 · Germline variants in SLCO1B1, thymidylate synthase, and methylenetetrahydrofolate reductase are significantly associated with kinetics, toxicity, and outcome. Abstract The pharmacogenetics of methotrexate (MTX) was investigated in a large cohort of pediatric patients with acute lymphoblastic leukemia (ALL). flights from prince george to kamloops

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Slco1b1 variation and disease therapy

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WebAug 23, 2024 · SLCO1B1 genetic variation has been associated with delayed MTX clearance and increased toxicity. The purpose of this study was to evaluate the association between … WebApr 11, 2024 · The emergence of high-throughput approaches has had a profound impact on personalized medicine, evolving the identification of inheritable variation to trajectory analyses of transient states and paving the way for the unveiling of response biomarkers. The utilization of the multi-layered pharmaco-omics data, including genomics, …

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WebJan 16, 2024 · We selected 5 cardiometabolic diseases (coronary artery disease, hypercholesterolemia, type 2 diabetes, atrial fibrillation, and venous thromboembolic disease) and response to drug therapy and ... WebAn SLCO1B1 variant with a C allele at nucleotide position rs4149056 has been associated with altered pharmacokinetics of the cholesterol-lowering drug simvastatin, as well as …

WebSLCO1B1 (solute carrier organic anion transporter family member 1B1) is a drug transporter that helps the body get rid of certain medicines through the liver. There are many … WebJul 7, 2024 · SLCO1B1 genotype information is increasingly being utilized to guide the selection and dosing of several statins, especially simvastatin. 15 - 17 Genetic variation in another transporter, ABCG2, and the gene encoding the drug metabolizing enzyme CYP2C9 have also been shown to be relevant for statin prescribing in addition to SLCO1B1 …

WebApr 13, 2024 · The Precision Medicine Initiative, launched by the US National Institutes of Health, uses cloud computing to store and analyze large volumes of genomic and clinical data to identify new treatments ... WebNov 3, 2009 · Under current nomenclature, the gene is known as SLCO1B1 and the protein as OATP1B1. 14 Several studies have shown OATP1B1 to be expressed exclusively on the basolateral (sinusoidal) membrane of...

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WebApr 18, 2007 · SLCO1B1 gene displays a number of single nucleotide polymorphisms (SNPs) that cause impaired transporter activity [ 13–16 ]. For example, clinical pharmacokinetic investigations in vivo have determined that SLCO1B1*15 haplotype is associated with a significant reduction in oral clearance of a single dose of pravastatin [ 13 ]. flights from prg to parWebThe SLCO1B1 gene encodes the organic anion transporting polypeptide (OATP) 1B1, which facilitates hepatic uptake of statins on the sinusoidal membrane of hepatocytes. 21,22 … flights from prince george to comox bcWebMay 1, 2024 · SLCO1B1 ( solute carrier organic anion transporter family member 1B1 ) is an important transmembrane hepatic uptake transporter. Genetic variants in the SLCO1B1 gene have been associated with altered protein folding, resulting in protein degradation and decreased transporter activity. Next-generation sequencing (NGS) of pharmacogenes is … flights from prg to spuWebMar 1, 2013 · SLCO1B1 gene solute carrier organic anion transporter family member 1B1 Normal Function The SLCO1B1 gene provides instructions for making a protein called … cherry beadsWebApr 9, 2024 · Variation ID: 37346 Description: single nucleotide variant Variant details Conditions Gene (s) Help NM_006446.5 (SLCO1B1):c.521T>C (p.Val174Ala) Allele ID 40587 Variant type single nucleotide variant Variant length 1 bp Cytogenetic location 12p12.1 Genomic location 12: 21178615 (GRCh38) GRCh38 UCSC 12: 21331549 (GRCh37) … cherry bean cafe taigumWebThe SLCO1B1 gene encodes the organic anion transporting polypeptide (OATP) 1B1, which facilitates hepatic uptake of statins on the sinusoidal membrane of hepatocytes. 21,22 Variations in SLCO1B1, c.-910G>A and c.521T>C (rs4149056), and haplotypes, *5, *15, and *17, have been reported to be associated with pharmacokinetic and lipid-lowering ... flights from prg to mucWebApr 10, 2024 · This clade is associated with cavitary disease, treatment failure, and demonstrates increased transmission potential. Interpretation: High-throughput phenogenotyping of Mtb clinical strains enabled bacterial intermediate trait identification that can provide a mechanistic link between Mtb genetic variation and patient clinical … flights from prince george bc to victoria bc