Cisplatin induced nephrotoxicity mechanism

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August undefined, 2024

WebSep 15, 2008 · Certain drugs are inherently nephrotoxic and include aminoglycosides, amphotericin B, cisplatin, contrast dye, and cyclosporine. 7, 34 For others, such as those associated with chronic ... Webrotection against gentamicin-induced nephrotoxicity in rats (Sandhya et al. 1995). Interestingly, the dose of an antioxi-dant lipoic acid (0.12–0.48 mmole/kg) required to protect cisplatin-induced nephrotoxicity (16 mg/kg) in rats was three to twelve times less than that of a chelating agent 4-

Molecular mechanisms of cisplatin-induced …

WebThe mechanisms mainly include the transport and metabolism of cisplatin, apoptosis, autophagy, DNA damage, oxidative stress, and inflammation, which work together to … WebMar 9, 2024 · The mechanism summary of cisplatin-induced nephrotoxicity. The mechanisms mainly include the transport and metabolism of cisplatin, apoptosis, autophagy, DNA damage, oxidative stress, and inflammation, which work together to aggravate AKI induced by cisplatin. how great chords

Cisplatin nephrotoxicity - PubMed

WebOct 13, 2024 · Preclinical studies have provided insights into the cellular and molecular mechanisms of cisplatin nephrotoxicity, which involve intracellular stresses including … WebMay 12, 2024 · The key of anti-tumor effect of cisplatin is damage to DNA of tumor, which also lead to renal injury. 2,3 Some reports link cisplatin poisoning with organelle dysfunction, such as endoplasmic reticulum, cytoskeleton, and mitochondria, both in vivo and in vitro. Apoptosis and necrosis of renal tubular cells play a major role in cisplatin … WebThe mechanisms of cisplatin-induced nephrotoxicity are complex and involve multiple pathways and molecules ( Figure 1) [ 92, 93 ]. The cellular pathways of cisplatin injury … how great is god to you

Direct impact of cisplatin on mitochondria induces ROS ... - Nature

WebNov 11, 2024 · Introduction. Cisplatin (CDDP), a platinum drug, has been universally utilized to treat bladder cancer, ovarian cancer and other solid tumors (Dasari and Tchounwou, 2014).However, the dominant factor restricting the clinical use of cisplatin is its nephrotoxicity (Zhu et al., 2015).Although hydration is extensively used to eliminate … WebMar 13, 2024 · Background: Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the … how great chanceWebMay 1, 2008 · Overview of the pathophysiological events in cisplatin nephrotoxicity. Cisplatin enters renal cells by passive and/or facilitated mechanisms. Exposure of … how great is china

"WebSep 1, 2024 · The mechanism of cisplatin-induced nephrotoxicity (CIN) has long been investigated in order to develop preventive/therapeutic drugs. Ferroptosis is a newly … " - Cisplatin induced nephrotoxicity mechanism

Cisplatin induced nephrotoxicity mechanism

Mechanism and reversal of drug-induced nephrotoxicity on a chip

WebDiscussion. In a previous study, we showed that DM was the high-risk factor for cisplatin-induced AKI. 5 However, no attempt was made to identify the mechanism for the … WebFeb 2, 2024 · Some studies have found that vinorelbine protects against cisplatin-induced acute kidney injury (AKI) by activating Nrf2/HO-1 signaling pathway and hindering TLR4-IFN-γ-CD44 cell inflammatory cascade when investigating the molecular mechanism of renal protection against nephrotoxicity (El-Sayed et al., 2024).

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WebOct 5, 2014 · The disproportionate accumulation of cisplatin in kidney tissue contributes to cisplatin-induced nephrotoxicity (Arany and Safirstein, 2003). Biosynthesis of amino acid lysine and methionine yields a quaternary ammonium compound called Carnitine, which is required for the transport of fatty acids from the cytosol into the mitochondria during ... WebFeb 2, 2024 · The mechanisms of cisplatin-induced acute kidney injury (AKI) are complex, and there are limited renoprotective approaches. Leonurine is the main active compound of a Chinese herb and has recently been …

WebJan 3, 2024 · Chemotherapy nephrotoxicity and dose modification in patients with kidney impairment: Molecularly targeted agents and immunotherapies; Cisplatin nephrotoxicity; Classic Kaposi sarcoma: Clinical features, staging, diagnosis, and treatment; Contrast-associated and contrast-induced acute kidney injury: Clinical features, diagnosis, and …

Webrotection against gentamicin-induced nephrotoxicity in rats (Sandhya et al. 1995). Interestingly, the dose of an antioxi-dant lipoic acid (0.12–0.48 mmole/kg) required to … WebNov 14, 2024 · The clinical application of cisplatin is limited by its adverse events, of which nephrotoxicity is the most commonly observed. In a cisplatin-induced pathological response, oxidative stress is one of the upstream reactions which inflicts different degrees of damages to the intracellular material components. Reactive oxygen species (ROS) are …

WebSep 1, 2024 · The mechanism of cisplatin-induced nephrotoxicity (CIN) has long been investigated in order to develop preventive/therapeutic drugs. Ferroptosis is a newly identified form of non-apoptotic regulated cell death induced by iron-mediated lipid peroxidation and is involved in the pathophysiology of various diseases. In this study, we …

WebMar 23, 2024 · For nearly five decades, cisplatin has played an important role as a standard chemotherapeutic agent and been prescribed to 10-20% of all cancer patients. Although nephrotoxicity associated with platinum-based agents is well recognized, treatment of cisplatin-induced acute kidney injury is mainly su … how great is are godWebCis-dichlorodiammine platinum (II), or cisplatin, is currently among the most widely used agents in the chemotherapy of cancer. The chief limit to its greater efficacy is its … highest paying jobs for women 2023WebMar 29, 2024 · The mechanisms associated with cisplatin-induced AKI (CIAKI) are complex, and the relationship between the key pathways remains unknown. However, it is believed that the detrimental … how great is heavenWebDec 16, 2024 · In this study, Cisplatin NanoComposite (Cis NC) was formulated successfully from irradiated chitosan coated Cisplatin and MgO nanoparticles … highest paying jobs gta onlineWebOct 11, 2024 · Experimentally induced sepsis (via LPS) also potentiates the degree of cisplatin-induced hearing loss in mice (Oh et al., 2011). LPS-induced inflammation in … how great depression cause world war 2WebDiscussion. In a previous study, we showed that DM was the high-risk factor for cisplatin-induced AKI. 5 However, no attempt was made to identify the mechanism for the development of AKI in patients with DM. MATE1/SLC47A1, an organic cation transporter in proximal tubular epithelial cells, mediates the tubular secretion of cationic drugs or … how great funWebOct 29, 2024 · There is evidence though that necrosis, oxidative stress, inflammation, and apoptosis may play crucial roles in cisplatin-induced nephrotoxicity 5. Cisplatin-induced nephrotoxicity... how great i am ali