Cisplatin chemistry

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WebJul 1, 2024 · Cisplatin is one of the best and first metal-based chemotherapeutic drugs (see Fig. 1 for 3D structure of cisplatin) [10], [287]. It is reported that ∼2 billion U.S. dollars of platinum-based anticancer drugs are sold worldwide [6], [7] and nearly about 50% of all patients are treated with cisplatin [8]. WebOct 5, 2014 · Cisplatin has a molecular weight of 301.1 gm/mol, a density of 3.74 g/cm 3, a melting point of 270° C, a log K ow of -2.19 and a water solubility of 2.53 g/L at 25° …

Cisplatin: chemistry, distribution and biotransformation

WebJun 10, 1999 · Medicinal bioinorganic chemistry - the role of metal compounds in medicine - has received an enormous boost from cisplatin, and so has bioinorganic chemistry as a whole. There is hardly a better example than cisplatin to demonstrate what bioinorganic chemistry is all about: The marriage between classic inorganic (coordination) chemistry … WebApr 15, 2024 · The treatment was well tolerated only he developed grade 2 mucositis and weight loss associated with cisplatin [ duration of treatment to reactions onset not stated … during what time was the great depression

Pt(IV) complexes as prodrugs for cisplatin - PubMed

Webtrans-Platinum(II) diamminedichloride Cl2H6N2Pt+2 CID 441203 - structure, chemical names, physical and chemical properties, classification, patents, literature ... WebThe antitumor effects of platinum(IV) complexes, considered prodrugs for cisplatin, are believed to be due to biological reduction of Pt(IV) to Pt(II), with the reduction products binding to DNA and other cellular targets. In this work we used pBR322 DNA to capture the products of reduction of oxopl … Pt(IV) complexes as prodrugs for cisplatin WebIntroduction: Cisplatin has been indicated for several malignancies all over the world for many years. Increasing patient tolerance for high dose of chemotherapeutics and reducing side effects has been granted by drug encapsulated liposomal systems. during which arc did raditz come to earth

Pharmaceutics Free Full-Text Pd (II) and Pt (II) Trinuclear ...

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WebJun 20, 2024 · Cisplatin [ cis- diamminedichloroplatinum (II) ( cis -DDP)] is one of the most successful anticancer agents employed today and is effective against a wide range of solid tumors ( 1 – 3 ), including neuroblastoma ( 4 ), the extracranial neoplasm most commonly diagnosed in childhood ( 5 ). WebThe microstructure and properties of metal ion-assisted cisplatin-loading SLNs were investigated by infra-red spectroscopy, fluorescence spectroscopy and zetasizer. The reactions of hydrogenated soybean lecithin with Zn(2+), Cu(2+), Mn(2+ )and Mg(2+ )have been detected; the mechanism for higher drug encapsulation efficiency (EE) has been ... during what time does darth vader liveWebDec 15, 2015 · This strategy was successful in delaying cis-diammineplatinum(II) dichloride (cisplatin, CDDP) leakage and averting spontaneous release under physiological conditions. Nevertheless, our carbon nanobottles were far from being “smart” in achieving controlled release of cargo molecules only in response to specific trigger. during what years was the great depression

"WebCisplatin, a platinum analogue, is an alkylating agent used in combination with other agents to treat a variety of solid malignancies, including lung cancer, head and neck cancer, … " - Cisplatin chemistry

Cisplatin chemistry

Exploring the Metabolic Differences between Cisplatin- and UV …

WebThe reactions of cisplatin [cis-diamminedichloroplatinum (II), CDDP] with glutathione (GSH) and drug thiols were investigated at 37 degrees C in 100 mM Tris-NO (3), pH approximately 7.4, using a clinically relevant concentration of CDDP (33 micro M), a large excess of GSH (16.5 mM), and [NaCl] of 4.62 mM. WebOne of the first known coordination compounds was Peyrone’s Chloride (also known as cis-diamminedichloroplatinum (II), or cis-DDP), first reported in 1845. This compound …

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WebCisplatin is a tiny little drug molecule that contains a platinum ion in the middle of a flat square with two chloride ions and two ammonia molecules making up the corners. …

WebIn the 1960s the drug cis-platin was discovered, which has been extremely effective in treating a number of different types cancer such as testicular, ovarian, cervical, breast, lung and brain cancer. Cancer cells grow and replicate much faster than normal cells. Cis-platin is a square planar molecule that has a geometric isomer with the side ... WebCisplatin is a platinum-based agent whose nephrotoxicity is thought related to the chloride in the cis position. Cisplatin gains entry into tubular cells via uptake by the OCT-2 …

WebCisplatin: Chemistry and Biochemistry of a Leading Anticancer Drug Wiley 30 years after its discovery as an antitumor agent, cisplatin represents today one of the most … WebHypoxia can induce chemoresistance, which is a significant clinical obstacle in cancer therapy. Here, we assessed development of hypoxia-induced chemoresistance (HICR) against free versus polymeric cisplatin micelles in a triple negative breast cancer cell line, MDA-MB-231. We then explored two strategies for the modulation of HICR against …

WebCisplatin or (SP-4-2)-diamminedichloridoplatinum(II) is one of the most potential and widely used drugs for the treatment of various solid cancers such as testicular, …

WebCisplatin coordinates to DNA mainly through certain nitrogen atoms of the DNA base pairs; these nitrogen atoms (specifically, the N7 atoms of purines) are free to coordinate to cisplatin because they do not form hydrogen bonds with any other … cryptocurrency payment services actWebIn addition to solubility limitations, cisplatin has also been shown to be a highly reactive molecule. The reactivity of cisplatin and other platinum complexes towards many … cryptocurrency payment providerCisplatin is a chemotherapy medication used to treat a number of cancers. These include testicular cancer, ovarian cancer, cervical cancer, bladder cancer, head and neck cancer, esophageal cancer, lung cancer, mesothelioma, brain tumors and neuroblastoma. It is given by injection into a vein. Common side effects include bone marrow suppression, hearing problems, incl… during what years did world war i occurWebJan 9, 2024 · Cancer Drug 49 Times More Potent than Cisplatin ... business news during which changes of state do atomsWebFeb 1, 2014 · Journal of Computational and Theoretical Nanoscience February 1, 2014. Behavior of one and two Cisplatin (Cp) molecules confined in (8, 0), (9, 0), (10, 0), (11, 0), (12, 0) (14, 0) and (9, 9) capped and opened single-walled carbon nanotubes (CNTs) is studied by means of ab-initio calculations. Optimized geometry of inclusion complexes … during what years did the silk road existWebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different … during which century did sikhism startWebThe discoverers of cisplatin observed an unexpected cell phenomenon, then they evaluated what they saw and came to an exciting hypothesis that something was changing cell behavior in a way that might be useful medically. But the first proofs must often come through prudent tests on animals as a necessary step on the way to use in humans during which eon did eukaryotes likely arise